Identifying the major lactate transporter of Toxoplasma gondii tachyzoites
نویسندگان
چکیده
منابع مشابه
Acidocalcisomes in Toxoplasma gondii tachyzoites.
Toxoplasma gondii tachyzoites were loaded with the fluorescent indicator fura 2 to investigate the transport mechanisms involved in maintaining their intracellular Ca2+ homoeostasis. The mitochondrial ATPase inhibitor oligomycin and the endoplasmic-reticulum Ca(2+)-ATPase inhibitor thapsigargin increased the intracellular Ca2+ concentration ([Ca2+]i), thus indicating the requirement for ATP and...
متن کاملImmunogenicity of Gamma-Irradiated Toxoplasma gondii Tachyzoites in Mice
The Immunogenicity of γ-irradiated tachyzoites of a highly virulent strain of Toxoplasma gondii (RH strain) was investigated. Immunized mice survived challenge infection and displayed increased interferon gamma (INF-γ ) production. On the other hand, nonimmunized controls died after 10 days and displayed a significantly decreased lymphoproliferative response to Concanavalin A (Con A). No tachyz...
متن کاملThe Ultrastructural Effects of Sulfachloropyrazine on Toxoplasma gondii Tachyzoites
BACKGROUND Toxoplasmosis is one of the most common parasitic infections of humans and other mammals. This study was aimed to understand the mechanism of action of veterinary medicine-sulfachloropyrazine (SPZ, 99.97%) against Toxoplasma gondii. METHODS T. gondii tachyzoites were soaked in PBS (as a control) or SPZ (250 mg/mL) for 2 h at 37 °C. After being processed, any ultrastructural changes...
متن کاملCloning of Major Surface Antigen (SAG1) Gene of Toxoplasma gondii Tachyzoites
Toxoplasma gondii is an obligate intracellular protozoon parasite of all the warm blooded animals including birds and humans. It completes a sexual part of its life cycle in the intestinal epithelial cell of the Felidae (definitive host) and an asexual part in warm blooded (intermediate host). Human is an accidental host who contracts infection through handling cat litter and gardening, ingesti...
متن کاملIdentification of compounds that suppress Toxoplasma gondii tachyzoites and bradyzoites
Drug treatment for toxoplasmosis is problematic, because current drugs cannot eradicate latent infection with Toxoplasma gondii and can cause bone marrow toxicity. Because latent infection remains after treatment, relapse of infection is a problem in both infections in immunocompromised patients and in congenitally infected patients. To identify lead compounds for novel drugs against Toxoplasma...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Scientific Reports
سال: 2021
ISSN: 2045-2322
DOI: 10.1038/s41598-021-86204-3